A possible route for the release of fatty acid from fatty acid-binding protein
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چکیده
منابع مشابه
Fatty acid-binding protein from embryonic chick retina resembles mammalian heart fatty acid-binding protein.
PURPOSE Fatty acid-binding proteins (FABP) make up a family of cytosolic proteins of unknown function found in many tissues, including the embryonic chick retina. To further understand its function in the developing retina, the protein from embryonic chicks was purified and characterized. The tissue distribution of this protein in embryonic and hatched chicks was determined using polyclonal ant...
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This article reviews our current understanding of the uptake of fatty acids by the enterocytes of the intestine. The micellar solubilization of fatty acids by bile salts and the factors regulating that process are discussed. The mechanism of how micellar solubilization of fatty acids promotes the uptake of fatty acids by enterocytes and their relative importance is reviewed. Additionally, discu...
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Intestinal fatty acid binding protein (IFABP) interacts with biological membranes and delivers fatty acid (FA) into them via a collisional mechanism. However, the membrane-bound structure of the protein and the pathway of FA transfer are not precisely known. We used molecular dynamics (MD) simulations with an implicit membrane model to determine the optimal orientation of apo- and holo-IFABP (b...
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Human muscle fatty acid-binding protein (M-FABP) is a 15 kDa cytosolic protein which may be involved in fatty acid transfer and modulation of non-esterified fatty acid concentration in heart, skeletal muscle, kidney and many other tissues. Crystallographic studies have suggested the importance of the amino acids Thr-40, Arg-106, Arg-126 and Tyr-128 for the hydrogen bonding network of the fatty ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1994
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3010459